Early Stage Leads

Alion develops therapeutics to treat Central Nervous System disorders and cancers.

Alion is developing a pipeline of small molecule therapeutics for the treatment of Alzheimer's disease, other CNS diseases and certain cancers.

Our focus is ion channels and integral membrane proteins that have been shown to be viable therapeutic targets.

Alion’s proprietary techniques can find small molecules that modulate specific ligand and voltage-gated ion channels, including the AMPA, NMDA, nAch receptors, calcium and potassium ion channels.

Activity or inactivity of ion channels in humans is associated with various diseases. By controlling the functions of specific ion channels, new therapies may be developed. A multi-billion dollar market exists for human ion receptor therapeutics. Twenty-eight ion receptor drugs –that address 5 disctinct targets- generate $12 billion in worldwide sales (Bioportfolio, 2004)

In addition to the development of a therapeutic pipeline, Alion offers early stage pharmaceutical drug development services. These include, identification of lead compounds by computational chemistry and biophysical sceening techniques.

Computational Chemistry

Alion has extensive computational chemistry experience and facilities. By utilizing computer aided drug design (CADD), we are able to develop models to search our 1.5 million, multi-conformational molecular database for compounds to test in appropriate assays.

Our techniques rapidly exclude the majority of molecules from any database, such that only about 400–700 molecules are selected for screening against a given therapeutic target.

Following the molecular modeling processes and providing a recombinant protein is available for a given therapeutic target, Alion designs and conducts biophysical assays to quickly identify molecules with high affinity for the target.

From our experience, typically 3-5% of the molecules selected by our models, show specific binding to a target molecule and have biological activity.

News & Events

  • Grants
    Alion has been awarded a competitive National Institute’s of Health grant (Therapeutic Discovery Project program), funded for projects that show significant potential to produce new and cost-saving therapies. Alion’s grant was awarded for the development of a unique therapeutic approach in the treatment of Alzheimer's disease.
  • Funding
    Alion has recently received additional private venture funding.
    Alion has been asked to enter into discussions to advance our Alzheimer’s and oncology programs with a major pharmaceutical company. In addition to Alion’s existing programs, we have been asked to provide computational chemistry and biophysical assays as part of an ongoing effort to develop a new therapeutics pipeline for a major international pharmaceutical company